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Fig. 4 | Cancer Cell International

Fig. 4

From: Mitochondrion-mediated iron accumulation promotes carcinogenesis and Warburg effect through reactive oxygen species in osteosarcoma

Fig. 4

Mitochondrion-mediated iron accumulation promotes Warburg effect through reactive oxygen species. ad Seahorse metabolic analysis of extracellular acidification (ECAR) and oxygen consumption rates (OCR) in both cell lines. e Mitochondrion iron accumulation was higher than that of cytoplasm. f Ferric ammonium citrate (FAC) increased mitoferrin 1 (SLC25A37) and mitoferrin 2 (SLC25A28) expression. g Ferric ammonium citrate (FAC) increased reactive oxygen species (ROS) production. h Depletion of mitoferrin 1 (SLC25A37) and mitoferrin 2 (SLC25A28) by shRNA rescued the ROS production by FAC (*p < 0.05, **p < 0.01, ns: no significant, mean ± SD, n = 3)

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