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Fig. 4 | Cancer Cell International

Fig. 4

From: Cryptotanshinone chemosensitivity potentiation by TW-37 in human oral cancer cell lines by targeting STAT3–Mcl-1 signaling

Fig. 4

TW-37 inhibits the STAT3 phosphorylation at Tyr705 and nuclear translocation. HSC-3 cell lines were treated with DMSO or 5-μM of TW-37 for 3 or 6 h. a Protein levels of p-STAT3 (Y705), p-STAT3 (S727), STAT3, p-STAT5 (Y694), and STAT5 were analyzed using Western blotting. Actin was used as a loading control. b The bar graphs represent mean ± SD of three independent experiments. *P < 0.05. c The expression of nuclear p-STAT3 (Y705) and signal transducer and activator of transcription 3 (STAT3) was detected using Western blotting. In addition, α-tubulin and Lamin B were used as specific markers for cytosolic or nuclear fraction, respectively. The bar graphs represent mean ± SD of three independent experiments. *P < 0.05

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