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Table 2 Summary of murine cell lines capable of orthotopic tumor formation

From: Development of syngeneic murine cell lines for use in immunocompetent orthotopic lung cancer models

Cell Line

Genotype

Sex

Treatment

Primary tumor size (mm)

Priamary tumor age

P1 time

P2 time

P3 time

P4 time

Total time in vivo

Time in culture

Time in orthotopic

Total time in vitro

Total Time

X577

KrasG12D

Smad4 fl/+

M

2 ul 1010 CMV-Cre

9

184

179

52

35

26

476

23

10

33

509

X911

KrasG12D

Tgfbr2fl/fl

M

2 ul 1010 SPC-Cre

12

202

99

49

  

350

26

27

53

403

E889

KrasG12D

Map3K7fl/fl

ROSAmTmG

M

2 ul 109 CMV-Cre

3

180

184

54

  

418

45

45

90

508

X381

KrasG12D

Pten fl/+.p53fl/+

ROSAmTmG

M

2 ul 1010 SPC-Cre

1–3

134

135

25

24

 

318

29

27

56

374

Y856

R26StopFLP110*fl/+ p53fl/+

F

2 ul 1010 CMV-Cre

6

78

81

   

159

125

24

149

308

Y143

C57BL/6

F

30ul 5 × 106 Ad-EA

3–5

99

203

46

  

348

53

25

78

426

  1. All times are in days