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Table 2 Summary of murine cell lines capable of orthotopic tumor formation

From: Development of syngeneic murine cell lines for use in immunocompetent orthotopic lung cancer models

Cell Line Genotype Sex Treatment Primary tumor size (mm) Priamary tumor age P1 time P2 time P3 time P4 time Total time in vivo Time in culture Time in orthotopic Total time in vitro Total Time
X577 KrasG12D
Smad4 fl/+
M 2 ul 1010 CMV-Cre 9 184 179 52 35 26 476 23 10 33 509
X911 KrasG12D
Tgfbr2fl/fl
M 2 ul 1010 SPC-Cre 12 202 99 49    350 26 27 53 403
E889 KrasG12D
Map3K7fl/fl
ROSAmTmG
M 2 ul 109 CMV-Cre 3 180 184 54    418 45 45 90 508
X381 KrasG12D
Pten fl/+.p53fl/+
ROSAmTmG
M 2 ul 1010 SPC-Cre 1–3 134 135 25 24   318 29 27 56 374
Y856 R26StopFLP110*fl/+ p53fl/+ F 2 ul 1010 CMV-Cre 6 78 81     159 125 24 149 308
Y143 C57BL/6 F 30ul 5 × 106 Ad-EA 3–5 99 203 46    348 53 25 78 426
  1. All times are in days