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Fig. 2 | Cancer Cell International

Fig. 2

From: Down-regulation of TRIB3 inhibits the progression of ovarian cancer via MEK/ERK signaling pathway

Fig. 2

TRIB3-siRNA inhibited proliferation and induced apoptosis and cell cycle arrest in ovarian cancer cells. a The expression of TRIB3 protein in five OC cell lines using western blot. b Downregulation of TRIB3 protein using western blot. c TRIB3-siRNA inhibited cell proliferation of ovarian cancer cells. d TRIB3-siRNA increased apoptosis of ovarian cancer cells. e G0/G1 phase arrest of ovarian cancer cells after TRIB3 siRNA transfection. f Western blot analysis showed that the expression of PCNA, Bcl2/Bax, cyclin D1 protein in ovarian cancer cells decreased after transfection with TRIB3-siRNA. For western blot, GAPDH was used as an internal control. Data are presented as mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001

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