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Fig. 1 | Cancer Cell International

Fig. 1

From: Long noncoding RNA MIR99AHG promotes gastric cancer progression by inducing EMT and inhibiting apoptosis via miR577/FOXP1 axis

Fig. 1

MIR99AHG upregulation was associated with aggressive clinicopathological traits and poor prognosis for GC. a Heatmap of up-regulated lncRNAs between GC tissues and adjacent normal tissues. The data were taken from the public microarray database. The right panel is the local zoom in on the left panel. b Relative expression of MIR99AHG in GC tissues and adjacent normal tissues in the GEO database. c Relative expression of MIR99AHG in GC tissues and normal tissues in the TCGA database. d Overall survival analysis of paired patient samples with GC based on MIR99AHG expression status (P < 0.01, log-rank). e Overall survival analysis of TCGA cases based on MIR99AHG expression status (P < 0.01, log-rank). f MIR99AHG expression was significantly higher in GC specimens than in the paired adjacent normal tissues. g, h MIR99AHG expression was significantly higher in patients with advanced TNM stage and lymph node metastasis. MIR99AHG expression was examined by qPCR and normalized to 18sRNA expression. i Relative expression of MIR99AHG in five gastric cancer cell lines (SGC7901, BGC823, MGC803, AGS and MKN45) and human normal gastric epithelial cell line (GES1) analyzed by quantitative RT-PCR. *p < 0.05, **p < 0.01 and ***p < 0.001 (two-way ANOVA)

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