Fig. 1

LINE-1 promoter is hypomethylated in colorectal non-advanced adenoma, advanced adenoma, and adenocarcinoma. a In the 5′ UTR of LINE-1, there is a cluster of 31 individual CpG sites. The two AQAMA detection probes in this study were able to bind the CpG sites 10, 11, and 12. b The univariate scatter/box plot shows the LINE-1 promoter hypomethylation index (LHI) for individual samples in non-advanced adenoma, advanced adenoma, and adenocarcinoma and their adjacent tissues. The Mann–Whitney test was used to analyze the significant differences between different groups of samples at the shown p-value. N.S.: not significant