Fig. 4

Somatic non-reference insertion of Alu elements in the genome of colorectal advanced adenomas. a The circos plot shows the incidence and location of Alu insertions in six advanced adenoma polyp tissue compared to one normal mucosa. The outer track shows the location of insertions in relation to cytobands of chromosomes. From outside to inside, the second track shows the genes targeted by insertions and target regions (promoters, exons, transcription termination regions, and 3′ UTR). The innermost heatmap track shows the incidence of insertion for each genomic region (see the left guide inset). b The region and number of Alu reference and non-reference insertions. c Percentage of Alu insertions in each of the genomic regions