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Fig. 5 | Cancer Cell International

Fig. 5

From: Promoter methylation, transcription, and retrotransposition of LINE-1 in colorectal adenomas and adenocarcinomas

Fig. 5

Somatic non-reference insertion of SVA elements in the genome of colorectal advanced adenomas. a The circos plot shows the incidence and location of SVA insertions in six advanced adenoma polyp tissue compared to one normal mucosa. The outer track shows the location of insertions in relation to cytobands of chromosomes. From outside to inside, the second track shows the genes targeted by insertions and target regions (promoters, introns, transcription termination regions, and 3′ UTR). The innermost heatmap track shows the incidence of insertion for each genomic region (see the left guide inset). b The region and number of SVA reference and non-reference insertions. c Percentage of SVA insertions in each of the genomic regions

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