Fig. 3
From: A novel role of Krüppel-like factor 8 as an apoptosis repressor in hepatocellular carcinoma
Knockout of KLF8 increased the H3K27ac level of apoptotic-related genes. a BETA activating/repressive function prediction of the transcriptome and H3K27ac data from KLF8KO-LM3 or LM3 cells. The red and the purple lines represent the up-regulated and down-regulated genes, respectively. The dashed line indicates the non-differentially expressed genes as background. Genes are cumulated by the rank on the basis of the regulatory potential score from high to low. P values that represent the significance of the UP or DOWN group distributions in the brackets are compared with the NON group by the Kolmogorov–Smirnov test. b Left, the H3K27 acetylation peak score of the top 100 genes differentially expressed as well as H3K27ac changed between KLF8KO-LM3 cells and control. Right, the hierarchical clustering of the top 100 genes in left. c GO analysis of the overlapped genes (differentially expressed as well as H3K27ac changed) with GO categories. The vertical axis represents the GO category, and the horizontal axis is the log of the P value. d KEGG analysis of these overlapped genes. The vertical axis is the pathway category, and the horizontal axis represents the log of the P value