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Fig. 5 | Cancer Cell International

Fig. 5

From: A novel role of Krüppel-like factor 8 as an apoptosis repressor in hepatocellular carcinoma

Fig. 5

HMGA2 and MMP7 participated in the anti-apoptotic effect mediated by KLF8. a, b A schematic map of the location (up), H3K27ac (medium) and KLF8 motifs (down) of HMGA2 (a) and MMP7 (b) in the chromosome. c Flow cytometry analysis after Annexin-V/PI staining in LM3 (left) or KLF8KO-LM3 (right) cells transfected with HMGA2 siRNA (HMGA2i) or control siRNA (Ctrli). d Flow cytometry analysis after Annexin-V/PI staining in LM3 (left) or KLF8KO-LM3 (right) cells transfected with MMP7 siRNA (MMP7i) or Ctrli. For the right panels of C and D, experiments were performed in triplicate and all data are shown as Mean ± SD. * P < 0.05 and *** P < 0.001. e Western blot analysis of cleaved Caspase3 in LM3 or KLF8KO-LM3 cells transfected with HMGA2i or Ctrli. f Western blot analysis of cleaved Caspase3 in LM3 or KLF8KO-LM3 cells transfected with MMP7i or Ctrli. For E and F, representative results from 3 independent experiments are shown

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