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Table 1 Cytotoxicity of NDV and MH combination or alone against AMJ13, MCF-7, and REF cells

From: Hexokinase inhibition using D-Mannoheptulose enhances oncolytic newcastle disease virus-mediated killing of breast cancer cells

Points

NDV (MOI)

MH (µg/ml)

CI

Effect

 A-AMJ13

  1

2

250

0.10595

Synergism

  2

2

125

0.24635

Synergism

  3

2

62.5

0.49989

Synergism

  4

1

250

0.20755

Synergism

  5

1

125

0.41359

Synergism

  6

1

62.5

0.49220

Synergism

  7

0.3

250

0.35256

Synergism

  8

0.3

125

0.34603

Synergism

  9

0.3

62.5

1.07844

Additive

 B-MCF-7

  1

2

250

0.06841

Synergism

  2

2

125

0.20042

Synergism

  3

2

62.5

0.51245

Synergism

  4

1

250

0.10016

Synergism

  5

1

125

0.15299

Synergism

  6

1

62.5

0.34948

Synergism

  7

0.3

250

0.09957

Synergism

  8

0.3

125

0.13597

Synergism

  9

0.3

62.5

0.22648

Synergism

 C-REF

  1

2

250

1.01291

Additive

  2

2

125

1.07549

Additive

  3

2

62.5

1.03328

Additive

  4

1

250

1.10258

Antagonism

  5

1

125

1.04811

Additive

  6

1

62.5

1.38593

Antagonism

  7

0.3

250

1.03584

Additive

  8

0.3

125

1.56003

Antagonism

  9

0.3

62.5

1.51414

Antagonism

  1. CI was measured by CompuSyn software. (A) CI values from the treatment of AMJ13 cancer cells; (B) CI values from treatment in MCF-7 cancer cells; (C) CI values from the treatment of non-cancer cells (REF)
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Cancer Cell International

ISSN: 1475-2867

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