Fig. 4

CircRAE1 serves as an oncogene by sponging miR-338-3p in CRC cells. a Non-significant alteration by miR-338-3P mimics of the relative expression of miR-338-3p or Significant reduction by the overexpression of CircRAE1 with LV-CircRAE1 of the miR-338-3p expression in SW620 and HT29 cells as determined by qRT-PCR. b, c Dramatic rescue by the overexpression of CircRAE1 of the cell proliferation ability of SW620 and HT29 cells induced by miR-338-3p mimics and vice versa. d Dramatic rescue by the overexpression of CircRAE1 of the impaired wound healing ability of SW620 and HT29 cells induced by miR-338-3p mimics and vice versa. e Dramatic rescue by the overexpression CircRAE1 of the impaired migration and invasion ability of SW620 and HT29 cells induced by miR-338-3p mimics and vice versa as detected by Transwell assays. f Protein level of TYRO3 in SW620 and HT29 as detected by Western blot assay. *P < 0.05, **P < 0.01, ***P < 0.001