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Fig. 7 | Cancer Cell International

Fig. 7

From: NONO promotes hepatocellular carcinoma progression by enhancing fatty acids biosynthesis through interacting with ACLY mRNA

Fig. 7

IGF2BP1, NONO and ACLY expressions contribute HCC development in mice and are related to poor survival. a IGF2BP1 or NONO knockout significantly inhibits tumor growth in vivo. Representative images of xenograft tumors from the nude mice. b Immunochemistry analysis of ACLY in tumor tissues (× 200 magnification). mRNA c Correlational analysis of NONO (C)/IGF2BP1 d protein and ACLY mRNA expression in clinical HCC tissues. e NONO mRNA expression analysis using TCGA database, and survival analysis of high or low expression of NONO on liver hepatocellular carcinoma patient from TCGA database (p = 0.00094). f IGF2BP1 mRNA expression analysis using TCGA database, and survival analysis of high or low expression of IGF2BP1 on liver hepatocellular carcinoma patient from TCGA database (p = 0.24). g ACLY mRNA expression analysis using TCGA database, and survival analysis of high or low expression of ACLY on liver hepatocellular carcinoma patient from TCGA database (p = 0.0087). Data are represented as mean ± SD (n = 3; *p < 0.05)

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