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Fig. 5 | Cancer Cell International

Fig. 5

From: CircRNA_104889 promotes lung adenocarcinoma cell invasion via sponging miR4458

Fig. 5

CircRNA_104889 activates the ERK1/2 pathway by up-regulating the caspase-3. a, b The mRNA level of the caspase-3 after knockdown of circRNA_104889 or overexpression of miR4458. c Representative images of western blots of caspase-3. d Quantification of caspase-3 protein expression from western blots. e Representative images of western blots of ERK1/2 and p-ERK1/2. f Quantification of pERK/ERK from western blots. g The schematic diagram showing the possible molecular mechanism of circRNA_104889-mediated metastasis of lung adenocarcinoma. Data are presented as mean ± SD from 3 independent experiments in triplicates, n = 3. Significant effect of the treatments,*p < 0.05, **p < 0.01, ***p < 0.001

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