Fig. 1

Differences in circRNA expression profiles between CRC and adjacent normal tissues. a Box plots show the distribution of circRNAs for the six samples (C for CRC and N for adjacent normal tissues). The distributions were nearly the same after normalization. b Unsupervised hierarchical clustering shows a distinguishable circRNA expression profiling among the six samples (C for CRC and N for adjacent normal tissues). Each column represents the expression profile of a tissues sample, and each row corresponds to a circRNA. “Red” indicates higher expression level and “green” indicated lower expression level. c Volcano plots showing differential expression of cicrRNA between the two groups. The red points represent the differentially expressed circRNAs with fold change ≥ 2.0 and P < 0.05