Fig. 2

Has_circ_0044556 significantly upregulated in CRC tissues and cells had possibility as a novel biomarker for CRC. a The expression levels of has_circ_0044556 in the CRC tissues are significantly higher than those in adjacent normal tissues. b Histogram and pie chart of the proportion of CRC samples in which has_circ_0044556 expression was upregulated (36/52, 69.23%, red_, downregulated (3/52, 5.77%, green), or no change (13,25.00%, gray). Log2(T/N expression) value > 1 as significantly higher expression, which < − 1 as lower expression, and between -1 and 1 as no significant change. c Receiver operating characteristics (ROC) curve of has_circ_0044556 was built for differentiating CRC tissues from controls. The area under curve was 0.7274, P < 0.0001. d The expression levels of has_circ_0044556 in the CRC cell lines and NCM460