Association of relapse-linked ARID5B single nucleotide polymorphisms with drug resistance in B-cell precursor acute lymphoblastic leukemia cell lines

Table 2 Comparison of SNP allele frequencies between BCP-ALL cell lines and the Japanese population

Chr position	SNP	Risk allele	72 BCP-ALL cell lines					HapMap JPT					OR (95%CI)	P value
Chr position	SNP	Risk allele	Genotype			Allelic frequency		Genotype			Allelic frequency		OR (95%CI)	P value
Susceptibility-linked
63,723,440	rs7923074	A	A/A	A/C	C/C	A	C	A/A	A/C	C/C	A	C	0.83	0.37
			(n = 20)	(n = 28)	(n = 24)	(n = 68)	(n = 76)	(n = 38)	(n = 102)	(n = 32)	(n = 178)	(n = 166)	(0.55–1.26)
			0.278	0.389	0.333	0.472	0.528	0.221	0.593	0.186	0.517	0.483
63,724,773	rs10821938	A	A/A	A/C	C/C	A	C	A/A	A/C	C/C	A	C	0.86	0.49
			(n = 20)	(n = 29)	(n = 23)	(n = 69)	(n = 75)	(n = 38)	(n = 102)	(n = 32)	(n = 178)	(n = 166)	(0.57–1.29)
			0.278	0.403	0.319	0.479	0.521	0.221	0.593	0.186	0.517	0.483
Relapse-linked
61,925,395	rs4948488	C	T/T	T/C	C/C	T	C	T/T	T/C	C/C	T	C	1.41	0.09
			(n = 30)	(n = 30)	(n = 12)	(n = 90)	(n = 54)	(n = 52)	(n = 82)	(n = 38)	(n = 186)	(n = 158)	(0.93–2.16)
			0.417	0.417	0.167	0.625	0.375	0.302	0.477	0.221	0.541	0.459
61,928,913	rs2893881	C	T/T	T/C	C/C	T	C	T/T	T/C	C/C	T	C	1.29	0.26
			(n = 34)	(n = 28)	(n = 10)	(n = 96)	(n = 48)	(n = 62)	(n = 80)	(n = 26)	(n = 204)	(n = 132)	(0.84–2.00)
			0.472	0.389	0.139	0.667	0.333	0.369	0.476	0.155	0.611	0.389
61,929,318	rs6479778	T	C/C	C/T	T/T	C	T	C/C	C/T	T/T	C	T	1.28	0.26
			(n = 35)	(n = 27)	(n = 10)	(n = 97)	(n = 47)	(n = 66)	(n = 80)	(n = 26)	(n = 212)	(n = 132)	(0.84–1.97)
			0.486	0.375	0.139	0.674	0.326	0.384	0.465	0.151	0.616	0.384

BCP-ALL B-cell precursor acute lymphoblastic leukemia, Chr chromosome, SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval

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