Skip to main content

Table 2 Comparison of SNP allele frequencies between BCP-ALL cell lines and the Japanese population

From: Association of relapse-linked ARID5B single nucleotide polymorphisms with drug resistance in B-cell precursor acute lymphoblastic leukemia cell lines

Chr position SNP Risk allele 72 BCP-ALL cell lines HapMap JPT OR (95%CI) P value
Genotype Allelic frequency Genotype Allelic frequency
Susceptibility-linked
 63,723,440 rs7923074 A A/A A/C C/C A C A/A A/C C/C A C 0.83 0.37
    (n = 20) (n = 28) (n = 24) (n = 68) (n = 76) (n = 38) (n = 102) (n = 32) (n = 178) (n = 166) (0.55–1.26)  
    0.278 0.389 0.333 0.472 0.528 0.221 0.593 0.186 0.517 0.483   
 63,724,773 rs10821938 A A/A A/C C/C A C A/A A/C C/C A C 0.86 0.49
    (n = 20) (n = 29) (n = 23) (n = 69) (n = 75) (n = 38) (n = 102) (n = 32) (n = 178) (n = 166) (0.57–1.29)  
    0.278 0.403 0.319 0.479 0.521 0.221 0.593 0.186 0.517 0.483   
Relapse-linked
 61,925,395 rs4948488 C T/T T/C C/C T C T/T T/C C/C T C 1.41 0.09
    (n = 30) (n = 30) (n = 12) (n = 90) (n = 54) (n = 52) (n = 82) (n = 38) (n = 186) (n = 158) (0.93–2.16)  
    0.417 0.417 0.167 0.625 0.375 0.302 0.477 0.221 0.541 0.459   
 61,928,913 rs2893881 C T/T T/C C/C T C T/T T/C C/C T C 1.29 0.26
    (n = 34) (n = 28) (n = 10) (n = 96) (n = 48) (n = 62) (n = 80) (n = 26) (n = 204) (n = 132) (0.84–2.00)  
    0.472 0.389 0.139 0.667 0.333 0.369 0.476 0.155 0.611 0.389   
 61,929,318 rs6479778 T C/C C/T T/T C T C/C C/T T/T C T 1.28 0.26
    (n = 35) (n = 27) (n = 10) (n = 97) (n = 47) (n = 66) (n = 80) (n = 26) (n = 212) (n = 132) (0.84–1.97)  
    0.486 0.375 0.139 0.674 0.326 0.384 0.465 0.151 0.616 0.384   
  1. BCP-ALL B-cell precursor acute lymphoblastic leukemia, Chr chromosome, SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval