|
Chr position
|
SNP
|
Risk allele
|
72 BCP-ALL cell lines
|
HapMap JPT
|
OR (95%CI)
|
P value
|
|---|
|
Genotype
|
Allelic frequency
|
Genotype
|
Allelic frequency
|
|---|
|
Susceptibility-linked
|
|
63,723,440
|
rs7923074
|
A
|
A/A
|
A/C
|
C/C
|
A
|
C
|
A/A
|
A/C
|
C/C
|
A
|
C
|
0.83
|
0.37
|
| | | |
(n = 20)
|
(n = 28)
|
(n = 24)
|
(n = 68)
|
(n = 76)
|
(n = 38)
|
(n = 102)
|
(n = 32)
|
(n = 178)
|
(n = 166)
|
(0.55–1.26)
| |
| | | |
0.278
|
0.389
|
0.333
|
0.472
|
0.528
|
0.221
|
0.593
|
0.186
|
0.517
|
0.483
| | |
|
63,724,773
|
rs10821938
|
A
|
A/A
|
A/C
|
C/C
|
A
|
C
|
A/A
|
A/C
|
C/C
|
A
|
C
|
0.86
|
0.49
|
| | | |
(n = 20)
|
(n = 29)
|
(n = 23)
|
(n = 69)
|
(n = 75)
|
(n = 38)
|
(n = 102)
|
(n = 32)
|
(n = 178)
|
(n = 166)
|
(0.57–1.29)
| |
| | | |
0.278
|
0.403
|
0.319
|
0.479
|
0.521
|
0.221
|
0.593
|
0.186
|
0.517
|
0.483
| | |
|
Relapse-linked
|
|
61,925,395
|
rs4948488
|
C
|
T/T
|
T/C
|
C/C
|
T
|
C
|
T/T
|
T/C
|
C/C
|
T
|
C
|
1.41
|
0.09
|
| | | |
(n = 30)
|
(n = 30)
|
(n = 12)
|
(n = 90)
|
(n = 54)
|
(n = 52)
|
(n = 82)
|
(n = 38)
|
(n = 186)
|
(n = 158)
|
(0.93–2.16)
| |
| | | |
0.417
|
0.417
|
0.167
|
0.625
|
0.375
|
0.302
|
0.477
|
0.221
|
0.541
|
0.459
| | |
|
61,928,913
|
rs2893881
|
C
|
T/T
|
T/C
|
C/C
|
T
|
C
|
T/T
|
T/C
|
C/C
|
T
|
C
|
1.29
|
0.26
|
| | | |
(n = 34)
|
(n = 28)
|
(n = 10)
|
(n = 96)
|
(n = 48)
|
(n = 62)
|
(n = 80)
|
(n = 26)
|
(n = 204)
|
(n = 132)
|
(0.84–2.00)
| |
| | | |
0.472
|
0.389
|
0.139
|
0.667
|
0.333
|
0.369
|
0.476
|
0.155
|
0.611
|
0.389
| | |
|
61,929,318
|
rs6479778
|
T
|
C/C
|
C/T
|
T/T
|
C
|
T
|
C/C
|
C/T
|
T/T
|
C
|
T
|
1.28
|
0.26
|
| | | |
(n = 35)
|
(n = 27)
|
(n = 10)
|
(n = 97)
|
(n = 47)
|
(n = 66)
|
(n = 80)
|
(n = 26)
|
(n = 212)
|
(n = 132)
|
(0.84–1.97)
| |
| | | |
0.486
|
0.375
|
0.139
|
0.674
|
0.326
|
0.384
|
0.465
|
0.151
|
0.616
|
0.384
| | |
- BCP-ALL B-cell precursor acute lymphoblastic leukemia, Chr chromosome, SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
