Table 2 Cox regression analysis of hazard ratio on NSCLC patients with diabetes mellitus

Gender, male vs. female

1.68 [1.04, 2.73]

–

–

Age (year), ≥ 60 vs. < 60

1.20 [0.76, 1.89]

–

–

BMI, ≥ 23.9 kg/m² vs. < 23.9 kg/m²

0.66 [0.43, 1.02]

0.68 [0.44, 1.05]

0.08

Serum CEA level, > 3.9 ng/mL vs. ≤ 3.9 ng/mL

1.43 [0.93, 2.19]

1.35 [0.88, 2.09]

0.172

Serum CRP level, > 9.49 μmol/L vs. ≤ 9.49 μmol/L

2.18 [1.41, 3.38]

2.08 [1.34, 3.23]

0.001**

Albumin level, ≤ 40.01 g/L vs. > 40.01 g/L

2.67 [1.73, 4.13]

2.53 [1.55, 4.11]

< 0.001***

Neutrophils count, > 4.68 × 10⁹/L vs. ≤ 4.68 × 10⁹/L

1.77 [1.15, 2.73]

1.61 [1.01, 2.57]

0.046***

Lymphocytes count, > 1.68 × 10⁹/L vs. ≤ 1.68 × 10⁹/L

0.70 [0.46, 1.08]

0.70 [0.46, 1.08]

0.109

Hemoglobin level, > 133 g/L vs. ≤ 133 g/L

0.70 [0.45, 1.07]

0.60 [0.39, 0.94]

0.024**

Platelet count, > 228.5 × 10⁹/L vs. ≤ 228.5 × 10⁹/L

1.42 [0.92, 2.18]

1.53 [0.99, 2.36]

0.057

PNI score, > 49.22 vs. ≤ 49.22

0.40 [0.26, 0.62]

0.42 [0.27, 0.66]

< 0.001***

NLR, > 2.9 vs. ≤ 2.9

1.85 [1.20, 2.85]

1.71 [1.09, 2.67]

0.019*

Pathologic type, Adenocarcinoma vs. others

1.01 [0.66, 1.54]

1.13 [0.72, 1.76]

0.601

Metastasis, Yes vs. No

1.66 [1.06, 2.60]

1.70 [1.09, 2.65]

0.02*

Stage of NSCLC, IV, III vs. II and I

2.01 [1.12, 3.62]

1.86 [1.01, 3.42]

0.048*

Surgery, Yes vs. No

0.27 [0.17, 0.45]

0.26 [0.15, 0.43]

< 0.001***

Therapy of radiation, Yes vs. No

1.36 [0.88, 2.09]

1.34 [0.85, 2.11]

0.21

Application of platinum, Yes vs. No

0.27 [0.08, 0.87]

0.32 [0.10, 1.06]

0.062

Target therapy, Yes vs. No

1.03 [0.65, 1.62]

1.09 [0.69, 1.72]

0.724

Application of TKI, Yes vs. No

1.12 [0.69, 1.81]

1.15 [0.71, 1.87]

0.567

Application of VEGF inhibitor, Yes vs. No

0.81 [0.40, 1.61]

0.74 [0.37, 1.48]

0.389

Chemotherapy, AP vs. others

0.83 [0.54, 1.28]

0.91 [0.59, 1.42]

0.685

Smoking, Yes vs. No

1.45 [0.94, 2.24]

1.02 [0.56, 1.87]

0.936

Hypertension, Yes vs. No

0.96 [0.62, 1.49]

0.88 [0.56, 1.39]

0.59

Hyperlipemia, Yes vs. No

0.61 [0.34, 1.09]

0.61 [0.34, 1.08]

0.089

Heart failure, Yes vs. No

12.63 [2.84, 56.17]

10.67 [2.38, 47.88]

0.002**

ACS, Yes vs. No

0.73 [0.18, 2.96]

0.82 [0.20, 3.37]

0.787

KPS score, > 80 vs. ≤ 80

0.27 [0.17, 0.43]

0.27 [0.17, 0.43]

< 0.001***

miR-1231, > 1.78 vs. ≤ 1.78

0.37 [0.23, 0.57]

0.36 [0.23, 0.57]

< 0.001***