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Table 2 Summarize the function of EVs contents in CCA

From: The role of extracellular vesicles in cholangiocarcinoma

EVs contents Source Downstream target or recipient cells Function References
DAMPs Actived cholangiocytes Macrophage Upregulate proinflammatory cytokines and profibrogenic factors [59]
Exosomes HUCCT1 and KMBC MSCs Contribute to tumor cell growth and stromal development [61]
Exosomes KKU-M213 H69 cell Induce the expression of β-catenin and reduce the expression of E-cadherin [64]
Exosomes RBE CIK cell Inhibit the antitumor activity of CIK cells [65]
MiR-205-5p KKU-M213 CCA cell Down-regulation of miR-205-5p can inhibit invasion and migration of CCA cells [73]
MiR-195 LX2 A rat model of CCA Inhibit CCA growth and improve survival in a rat model of CCA [77]
MiR-30e HuCCT1 CCA cell Inhibit CCA cell invasion and migration via inhibit EMT [81]
Circ-0000284 HuCCT1 and RBE Gene LY6E Enhancing the migration, invasion and proliferation of CCA cells [86]
  1. CCA cell lines: KKU-M213, KMBC, RBE and HuCCT-1. Normal human cholangiocyte cell line: H69. A human liver stellate cell line: LX2