Fig. 2

Regulatory co-factors of KLF5 in CRC. a, b The orange bar represents the proportion of the ChIP-Seq profiles of AR (a) and HSF1 (b) whose targets were enriched with KLF5’s, while the grey bar represents the proportion at random. c Common lncRNA targets of KLF5 and AR. The bar represents the percentage of the gene that was detected by ChIP-Seq profiles corresponding to AR. The red bar represents the up-regulated genes in CRC while the green bar represents the down-regulated genes in CRC. d The common PCG targets of KLF5 and HSF1. The bar represents the percentage of the gene that was detected in the ChIP-Seq profiles corresponding to HSF. The red bar represents the up-regulated genes in CRC. The picture shows the top 10 PCGs. e Network visualization of the co-regulatory network for KLF5 in CRC. The squares nodes represents the PCG, the circle nodes represents TF while the diamond nodes represents lncRNA. Furthermore, the width of the edge represents the percentage of ChIP-Seq profiles that detected the gene as the target of the corresponding TF (AR or HSF1)