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Fig. 9 | Cancer Cell International

Fig. 9

From: MicroRNA-221-3p is related to survival and promotes tumour progression in pancreatic cancer: a comprehensive study on functions and clinicopathological value

Fig. 9

miR-221-3p upregulation suppresses apoptosis in PC cells. Apoptosis was represented by a percentage (Q2 + Q3)/(Q1 + Q2 + Q3 + Q4). a After BxPC-3 cells were infected with control or mimic, apoptosis rates were tested with flow cytometry experiments. The apoptosis proportion was obviously decreased in BxPC-3 cells with miR-221-3p overexpression. b After BxPC-3 cells were infected with control or inhibitor, apoptosis rates were tested with flow cytometry experiments. The apoptosis proportion was increased in BxPC-3 cells with miR-221-3p overexpression. c After MIA PaCa-2 cells were infected with control or mimic, apoptosis rates were tested with flow cytometry experiments. The apoptosis proportion was decreased in MIA PaCa-2 cells with miR-221-3p overexpression. d After MIA PaCa-2 cells were infected with control or inhibitor, apoptosis rates were tested with flow cytometry experiments. The apoptosis proportion was increased in BxPC-3 cells with miR-221-3p overexpression. Three replicates were performed for this experiment. The results were analysed with t tests (unpaired), and significant p-values were defined as less than 0.05

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