Fig. 2

Down-regulation of LINC02418 inhibited tumor growth, cell mobility and cell invasion. a HCT116 and LoVo cells were transfected with three shRNAs targeting LINC02418 and control sh-NC. The cells were harvested at 48 h post transfection, and qRT-PCR was conducted to measure LINC02418 level. b, c Cell proliferation of HCT116 and LoVo cells were determined via CCK-8 assays (b) and colony formation assays (c). d, e Tumor volume curve and tumor wet weight of mice subcutaneously injected with HCT116 (d) and LoVo (e) cells which were stably transduced with sh-LINC02418 or sh-NC. f Transwell assay were performed to determine the effect of LINC02418 on the migration and invasion ability of HCT116 and LoVo cells. The results were expressed as the number of invaded cells per field. The error bars stand for standard deviation (SD). Data were representatives of three independent experiments with similar results; **P < 0.01, compared to sh-NC group; ns, no difference, compared to control group