Fig. 3

LINC02418 was a ceRNA for miR-34b-5p in CRC cells. a The putative binding sites of miR-34b-5p to wild type LINC02418 (LINC02418-WT), and the mutant LINC02418 (LINC02418-MUT). b Luciferase activities of HCT116 and LoVo cells co-transfected with miR-34b-5p mimic/miR-NC and luciferase reporters harboring LINC02418-WT or LINC02418-MUT were measured by dual luciferase assays; **P < 0.01; ns, no difference, compared to miR-NC group. c The effect of knockdown of LINC02418 on miR-34b-5p expression in CRC cells were quantified by qRT-PCR; **P < 0.01, compared to sh-NC group. d The differential expression of miR-34b-5p in CRC and normal tissues were analyzed by qRT-PCR. e, f The negative correlation between miR-34b-5p and LINC02418 levels was presented and determined by Pearson’s correlation curve and FISH experiments, respectively. The error bars stand for standard deviation (SD). Data were representatives of three independent experiments with similar results