Fig. 4

ALT inhibits the growth of acute lymphoblastic leukemia in vivo. BV173 cells transfected with AP2M1 siRNA in 100 μl PBS were subcutaneously injected into the posterior flank region of nude mice. After 15 days, mice were treated with ALT once daily. a Images of xenograft tumors dissected from each mouse. b Tumor volumes are indicated by the curves representing the trend in the increase in tumor size. c Mean weight of tumors. ^*P < 0.05. ALT, alantolactone; AP2M1, adaptor related protein complex 2 subunit mu 1