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Fig. 6 | Cancer Cell International

Fig. 6

From: Down-regulation of lncRNA UCA1 enhances radiosensitivity in prostate cancer by suppressing EIF4G1 expression via sponging miR-331-3p

Fig. 6

UCA1 regulated the expression of EIF4G1 via sponging miR-331-3p. a Bioinformatics (StarBase v3.0 software online) predicted the complementary binding sites between miR-331-3p and UCA1 or EIF4G1. b, c The direct combination between UCA1 and miR-331-3p in 22RV1 (b) and DU145 (c) was verified by dual-luciferase reporter assay. d, e The directive binding sequences between 3′UTR EIF4G1 and miR-331-3p in 22RV1 (d) and DU145 (e) were verified by dual-luciferase reporter assay. f–g QRT-PCR was used to evaluate the level of miR-331-3p in PCa tissues (f) and cells (g). h, i The correlation analysis between miR-331-3p and UCA1 or EIF4G1 was presented. j, k QRT-PCR or western blot assay was carried out to detect the mRNA (j) or protein (k) expression of EIF4G1 in PCa cells, respectively. *P < 0.05

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Cancer Cell International

ISSN: 1475-2867

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