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Fig. 4 | Cancer Cell International

Fig. 4

From: HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway

Fig. 4

Silencing HKDC1 inhibited proliferation, invasion, and migration in vitro and tumorigenesis in vivo. a, b The mRNA (a) and protein level (b) of HKDC1 was detected after transfected with sh-HKDC1 in both A549 and H1299 cells. c The viability of LUAD cells with sh-HKDC1 was decreased by CCK-8 assay. d, e Knockdown of HKDC1 inhibited A549 (d) and H1299 (e) cells migration and invasion in vitro as assessed by the wound healing assay (scale bar, 100 μm). f HKDC1 knockdown inhibited tumor growth in vivo. Data were expressed as the mean ± standard deviation (mean ± SD) *p < 0.05, **p < 0.01

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