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Fig. 5 | Cancer Cell International

Fig. 5

From: HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway

Fig. 5

HKDC1 regulated glycolysis, epithelial–mesenchymal transition, and AMPK/mTOR signaling pathway in LUAD cells. a Overexpression of HKDC1 promoted glucose consumption and lactate production in both A549 and H1299 cells. b Silencing HKDC1 reduced glucose consumption and lactate production in both A549 and H1299 cells. c Overexpression of HKDC1 promoted the expression of N-cadherin, Snail, and Vimentin while decreased the expression of E-cadherin in LUAD cells. d Silencing HKDC1 decreasing the expression of N-cadherin, Snail, and Vimentin while increasing the expression of E-cadherin in LUAD cells. e, f HKDC1 regulated the expression of p-AMPK, p-mTOR and p-p70S6 in LUAD cells. Data were expressed as the mean ± standard deviation (mean ± SD) *p < 0.05, **p < 0.01

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Cancer Cell International

ISSN: 1475-2867

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