HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway

Table 2 Univariate and multivariate survival analysis for patients with LUAD

Characteristic	HR	95% CI	p value
Univariate analysis
Age (≤ 55 vs > 55)	1.277	0.697–2.338	0.428
Sex (male vs female)	1.677	0.930–3.024	0.086
Location (left vs right)	1.582	0.891–2.811	0.118
Differentiation (poor vs well + moderate)	2.682	1.501–4.794	0.001
pT stage (T3–4 vs T1–2)	3.259	1.820–5.836	< 0.001
pN stage (N+ vs N0)	5.835	3.007–11.323	< 0.001
HKDC1 expression (high vs low)	2.625	1.265–5.448	0.010
Multivariate analysis
Differentiation (poor vs well + moderate)	1.276	0.644–2.528	0.485
pT stage (T3–4 vs T1–2)	2.245	1.185–4.253	0.013
pN stage (N+ vs N0)	4.561	2.062–10.089	< 0.001
HKDC1 expression (high vs low)	2.598	1.176–5.739	0.018

ISSN: 1475-2867