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Fig. 7 | Cancer Cell International

Fig. 7

From: Epigenetic regulation of osteopontin splicing isoform c defines its role as a microenvironmental factor to promote the survival of colon cancer cells from 5-FU treatment

Fig. 7

Evaluation of OPNc expression associated with MeCP2 protein phosphorylation in clinical colorectal cancer tissues. a Relative mRNA levels of OPN splicing isoforms in colon cancer tissues (n = 325) and the adjacent tissues (n = 193). b Immunohistochemistry for p-MeCP2(S421), MeCP2 and 5mC in tissue sections selected from cancer samples of low or high ratios in OPNc/OPNa from RT-qPCR measures (n = 15). c, d Quantified staining intensity of p-MeCP2 and MeCP2 levels from (b). e Statistics on DNA methylation by 5-mC staining in OPNc/OPNa high or low groups. **p < 0.01, ***p < 0.001

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Cancer Cell International

ISSN: 1475-2867

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