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Fig. 3 | Cancer Cell International

Fig. 3

From: CircUBE2D2 (hsa_circ_0005728) promotes cell proliferation, metastasis and chemoresistance in triple-negative breast cancer by regulating miR-512-3p/CDCA3 axis

Fig. 3

Knockdown of circUBE2D2 inhibits TNBC progression in vitro and in vivo. a The interfering efficiency of two siRNAs targeting circUBE2D2 (circUBE2D2 #1 and circUBE2D2 #2) were examined by qRT-PCR. b and c CCK-8 and colony formation assays were conducted to determine the influence of circUBE2D2 silencing on TNBC cell proliferation. d and e Cell migration and invasion were detected by transwell assay in MDA-MB-231 and BT-549 cells transfected with si-circUBE2D2 #1 or si-circUBE2D2 #2. f Xenografts growth curves during the time course of 27 days. g Tumor weights were monitored after the nude mice were euthanized. h CircUBE2D2 expression analysis in the resected tumor tissues. i Western blot analysis of Ki-67 protein in tumors excised from mice. **P < 0.01, ***P < 0.001

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