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Fig. 7 | Cancer Cell International

Fig. 7

From: CircUBE2D2 (hsa_circ_0005728) promotes cell proliferation, metastasis and chemoresistance in triple-negative breast cancer by regulating miR-512-3p/CDCA3 axis

Fig. 7

Down-regulation of miR-512-3p or overexpression of CDCA3 antagonizes the anti-cancer effects induced by circUBE2D2 knockdown in TNBC cells. ae MiR-512-3p inhibitor (anti-miR-512-3p) or CDCA3-overexpression plasmid (CDCA3) was transfected into MDA-MB-231 and BT-549 cells with circUBE2D2 knockdown. a The expression level of miR-512-3p was measured by qRT-PCR. b and c The cell proliferation ability was examined by CCK-8 and colony formation assays. d and e The cell migration and invasion were evaluated by transwell assay. *P < 0.05, **P < 0.01, ***P < 0.001

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