Fig. 8

CircUBE2D2 induced doxorubicin resistance in TNBC cells through regulating miR-512-3p/CDCA3. a and b Transfected MDA-MB-231 and BT-549 cells were treated with different doses of doxorubicin (0.01, 0.1, 1, 5, 10, 50 or 100 μM) for 48 h, and the cell viability and IC₅₀ values of doxorubicin were then determined using a CCK-8 assay. c Transfected MDA-MB-231 and BT-549 cells were treated with or without 2 μM doxorubicin for 48 h, and cell apoptosis was then assessed by flow cytometry. **P < 0.01, ***P < 0.001