Fig. 2
From: The Ibr-7 derivative of ibrutinib radiosensitizes pancreatic cancer cells by downregulating p-EGFR
Ibr-7 sensitized pancreatic cancer cells to radiation. A representative image of colony formation in PANC-1 and Capan2 cells treated with radiation alone or with Ibr-7 (2 μmol/L) and radiation (0, 2, 4, 6 Gy) (a, b). Clonogenic cell survival assays were performed for PANC-1 and Capan2 cells that were treated with Ibr-7 (2 μmol/L) or DMSO for 24 h, then were exposed to different doses of γ-radiation. A multi-target click mathematical model simulated the cell survival fraction curve (c, d). Results shown are the mean ± SD of 3 independent experiments. Significance was determined by Student’s t-test (*p < 0.05 compared with combination group)