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Table 2 The radiosensitization activity of PANC-1 and Capan2 cells treated with or without Ibr-7

From: The Ibr-7 derivative of ibrutinib radiosensitizes pancreatic cancer cells by downregulating p-EGFR

  K N D0/Gy Dq/Gy SF2 SERSF2
PANC-1
 IR 1.134 9.097 0.88 1.94 63.05 ± 0.08
 IR + Ibr 1.492 9.432 0.67 1.50 38.69 ± 0.02* 1.63
Capan2
 IR 1.044 13.89 0.96 2.53 84.20 ± 0.02
 IR + Ibr 1.105 6.462 0.90 1.68 52.85 ± 0.01*** 1.59
  1. K, a passivation constant, derived directly from the fitting equation; N, extrapolation number, derived directly from the fitting equation; D0, mean lethal dose; Dq, quasithreshold dose; SF2, survival fraction (2 Gy); SER, sensitization enhancement ratio
  2. * p < 0.05, *** p < 0.001