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Table 2 The radiosensitization activity of PANC-1 and Capan2 cells treated with or without Ibr-7

From: The Ibr-7 derivative of ibrutinib radiosensitizes pancreatic cancer cells by downregulating p-EGFR

 

K

N

D0/Gy

Dq/Gy

SF2

SERSF2

PANC-1

 IR

1.134

9.097

0.88

1.94

63.05 ± 0.08

–

 IR + Ibr

1.492

9.432

0.67

1.50

38.69 ± 0.02*

1.63

Capan2

 IR

1.044

13.89

0.96

2.53

84.20 ± 0.02

–

 IR + Ibr

1.105

6.462

0.90

1.68

52.85 ± 0.01***

1.59

  1. K, a passivation constant, derived directly from the fitting equation; N, extrapolation number, derived directly from the fitting equation; D0, mean lethal dose; Dq, quasithreshold dose; SF2, survival fraction (2 Gy); SER, sensitization enhancement ratio
  2. * p < 0.05, *** p < 0.001
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Cancer Cell International

ISSN: 1475-2867

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