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Fig. 2 | Cancer Cell International

Fig. 2

From: Long non-coding RNA MALAT1 regulates oxaliplatin-resistance via miR-324-3p/ADAM17 axis in colorectal cancer cells

Fig. 2

Knockdown of MALAT1 could augment the sensitivity response to Ox in HCT116/OxR and HCT8/OxR cells. aj HCT116/OxR and HCT8/OxR cells were transfected with sh-NC or sh-MALAT1. a The knockdown efficiency of sh-MALAT1 in HCT116/OxR and HCT8/OxR cells. b, c The detection of IC50 value of Ox in HCT116/OxR and HCT8/OxR cells. d, e Measurement of cell viability by CCK-8 assay. f, g Measurement of cell migration HCT116/OxR and HCT8/OxR cells by transwell assay. h Determination of cell apoptosis in HCT116/OxR and HCT8/OxR cells by flow cytometry. i, j The expression of Bcl-2, Cleaved caspase-3, E-cadherin and Vimentin was detected by western blot. N = 3, *P < 0.05

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