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Fig. 4 | Cancer Cell International

Fig. 4

From: Long non-coding RNA MALAT1 regulates oxaliplatin-resistance via miR-324-3p/ADAM17 axis in colorectal cancer cells

Fig. 4

ADAM17 was a target of miR-324-3p. a The complementary sequences between miR-324-3p and ADAM17. b, c The fluorescence intensities of ADAM17-WT and ADAM17-MUT in HCT116/OxR and HCT8/OxR cells transfected with miR-324-3p. d, e Measurement of ADAM17 mRNA and protein expression in Ox-resistant CRC tissues (n = 40) and Ox-sensitive CRC tissues (n = 40). f The relationship between miR-324-3p and ADAM17 in Ox-resistant CRC tissues (n = 40). g, h Detection of ADAM17 mRNA and protein expression in Ox-resistant CRC cells, CRC cells, and FHC cells. i, j The protein expression of ADAM17 in HCT116/OxR and HCT8/OxR cells transfected with sh-NC, sh-MALAT1, sh-MALAT1 + miR-NC, or sh-MALAT1 + miR-324-3p. N = 3, *P < 0.05

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