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Fig. 5 | Cancer Cell International

Fig. 5

From: Long non-coding RNA MALAT1 regulates oxaliplatin-resistance via miR-324-3p/ADAM17 axis in colorectal cancer cells

Fig. 5

ADAM17 up regulation could abrogate the effect of MALAT1 reduction on the sensitivity of Ox-resistant CRC cells. a, b The transfection efficiency of ADAM17 in Ox-resistant CRC cells. ck HCT116/OxR and HCT8/OxR cells were transfected with sh-NC, sh-MALAT1, sh-MALAT1 + pcDNA, or sh-MALAT1 + ADAM17. c, d The detection of IC50 value of Ox in HCT116/OxR and HCT8/OxR cells. e, f Measurement of cell viability by CCK-8 assay. g, h Measurement of cell migration HCT116/OxR and HCT8/OxR cells by transwell assay. i Determination of cell apoptosis in HCT116/OxR and HCT8/OxR cells by flow cytometry. j, k The expression of Bcl-2, Cleaved caspase-3, E-cadherin and Vimentin was detected by western blot. N = 3, *P < 0.05

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