Research progress on long non-coding RNAs and their roles as potential biomarkers for diagnosis and prognosis in pancreatic cancer

Table 2 LncRNAs interacting with histone modifiers in pancreatic cancer

LncRNA	Molecule(s) interacting with lncRNA	Affected molecules	Epigenetic regulation caused by lncRNA on target genes	References
AGAP2-AS1	EZH2	ANKRD1 and ANGPTL4	Silencing of ANKRD1 and ANGPTL4	[49]
SNHG15	EZH2	P15 and KLF2	Inhibition of P15 and KLF2	[50]
TUG1	EZH2	RND3 and MT2A	Repressing of RND3 and MT2A	[51]
DUXAP10	EZH2 and LSD1	SMAD4 and KLF2	Silencing of SMAD4 and KLF2	[52]
IRAIN	EZH2 and LSD1	P15 and KLF2	Silencing of KLF2 and P15	[53]
HOXA-AS1	EZH2 and LSD1	–	–	[54]
HOTAIR	EZH2	DR5	Decrease the expression of DR5	[55]
SNHG14	EZH2	E-cadherin	Silencing the expression of E-cadherin	[56]

EZH2, Enhancer of zeste homolog 2; ANKRD1, Ankyrin repeat protein 1; ANGPTL4, Angiopoietin-like 4; SNHG, Small nucleolar RNA host gene; KLF2, Kruppel-like factor 2; TUG1, Taurine upregulated 1; RND3, Rho family GTPase 3; MT2A, Metallothionein 2A; LSD1, Lysine demethylase 1; SMAD4, SMAD family member 4; IRAIN, IGF1R antisense imprinted non-protein coding RNA; HOXA-AS1, HOXA cluster antisense RNA 2; HOTAIR, HOX transcript antisense RNA; DR5, Death receptor 5

ISSN: 1475-2867