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Table 2 LncRNAs interacting with histone modifiers in pancreatic cancer

From: Research progress on long non-coding RNAs and their roles as potential biomarkers for diagnosis and prognosis in pancreatic cancer

LncRNA Molecule(s) interacting with lncRNA Affected molecules Epigenetic regulation caused by lncRNA on target genes References
AGAP2-AS1 EZH2 ANKRD1 and ANGPTL4 Silencing of ANKRD1 and ANGPTL4 [49]
SNHG15 EZH2 P15 and KLF2 Inhibition of P15 and KLF2 [50]
TUG1 EZH2 RND3 and MT2A Repressing of RND3 and MT2A [51]
DUXAP10 EZH2 and LSD1 SMAD4 and KLF2 Silencing of SMAD4 and KLF2 [52]
IRAIN EZH2 and LSD1 P15 and KLF2 Silencing of KLF2 and P15 [53]
HOXA-AS1 EZH2 and LSD1 [54]
HOTAIR EZH2 DR5 Decrease the expression of DR5 [55]
SNHG14 EZH2 E-cadherin Silencing the expression of E-cadherin [56]
  1. EZH2, Enhancer of zeste homolog 2; ANKRD1, Ankyrin repeat protein 1; ANGPTL4, Angiopoietin-like 4; SNHG, Small nucleolar RNA host gene; KLF2, Kruppel-like factor 2; TUG1, Taurine upregulated 1; RND3, Rho family GTPase 3; MT2A, Metallothionein 2A; LSD1, Lysine demethylase 1; SMAD4, SMAD family member 4; IRAIN, IGF1R antisense imprinted non-protein coding RNA; HOXA-AS1, HOXA cluster antisense RNA 2; HOTAIR, HOX transcript antisense RNA; DR5, Death receptor 5