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Fig. 2 | Cancer Cell International

Fig. 2

From: Inhibition of let-7b-5p contributes to an anti-tumorigenic macrophage phenotype through the SOCS1/STAT pathway in prostate cancer

Fig. 2

Effect of let-7b-5p on the expression of inflammatory cytokines in macrophages. M0, M1, and M-CMs were differentiated as described in “Materials and methods”. M-CMs were transfected with let-7b-5p inhibitors or NC, or remained untreated for 72 h; M1 macrophages were transfected with let-7b-5p mimics. Expression of IL-12, IL-13, IL-10, and TNF-α was determined by qPCR. Expression of mRNA was normalized to GAPDH. Data represent the mean ± SD of 3 separate experiments. *P < 0.05; **P < 0.01

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