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Fig. 3 | Cancer Cell International

Fig. 3

From: Inhibition of let-7b-5p contributes to an anti-tumorigenic macrophage phenotype through the SOCS1/STAT pathway in prostate cancer

Fig. 3

SOCS1 is a direct target gene of let-7b-5p in vitro. a Protein expression of SOCS1 in macrophages of each group. Expression of SOCS1 protein was confirmed by ELISA after M1 or M-CMs were transfected with let-7b-5p mimics or inhibitors, respectively, for 72 h, compared with the respective controls. b Illustration of the sequence match between let-7b-5p and SOCS1 3′-UTR as determined using TargetScan. c Relative luciferase activity was assayed and calculated by the ratio of firefly-Renilla luciferase activity following transfection with let-7b-5p mimic compared with transfection with NC in 293 T. The data are shown as the mean ± SD of 3 separate experiments. *P < 0.05; **P < 0.01

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