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Table 1 Univariable and multivariable Cox regression analysis for prediction of RFS in TCGA database

From: Identification and validation of methylation-driven genes prognostic signature for recurrence of laryngeal squamous cell carcinoma by integrated bioinformatics analysis

Factors Subgroup Univariable analysis Multivariable analysis
HR(95% CI) P HR(95% CI) P
Age   0.96 (0.92–1.00) 0.094 NA NA
Sex Female 1    
  Male 0.85 (0.26–2.85) 0.795 NA NA
Smoking history No 1    
  Yes 1.47(0.69–3.10) 0.319 NA NA
Alcohol history No 1    
  Yes 1.21 (0.51–2.90) 0.668 NA NA
Number of Lymph nodes   0.99 (0.97–1.00) 0.305 NA NA
Number of positive LNs   1.00 (0.94–1.05) 0.878 NA NA
Lymph node ratio   2.02 (0.37–10.95) 0.417 NA NA
Margin status Negative 1   1  
  Positive 6.24(2.53–16.28) 0.000* 3.45(1.05–11.35) 0.042*
Lymphovascular No 1    
invasion Yes 2.00(0.71–5.66) 0.192 NA NA
Tumor grade G1–G2 1    
  G3–G4 0.97(0.43–2.20) 0.942 NA NA
Clinical T T1–T2 1    
  T3–T4 0.96(0.29–3.23) 0.949 NA NA
Clinical N N0 1    
  N1–N3 1.86(0.84–4.12) 0.123 NA NA
Clinical stage I–II 1    
  III–IV 0.53(0.007–4.02) 0.540 NA NA
Mutation count   0.99(0.98–1.01) 0.185 NA NA
Fraction Genome altered   0.73(0.07–7.43) 0.788 NA NA
MDGPS   1.43(1.23–1.67) 0.000* 1.29 (1.06–1.60) 0.010*
  1. HR hazard ratio, CI confidence intervals, RFS recurrence-free survival, NA not available
  2. These variables were eliminated in the multivariate cox regression model, so the HR and P values were not available. *P < 0.05