Table 1 Univariable and multivariable Cox regression analysis for prediction of RFS in TCGA database
Factors | Subgroup | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|---|
HR(95% CI) | P | HR(95% CI) | P | ||
Age |  | 0.96 (0.92–1.00) | 0.094 | NA | NA |
Sex | Female | 1 | Â | Â | Â |
|  | Male | 0.85 (0.26–2.85) | 0.795 | NA | NA |
Smoking history | No | 1 | Â | Â | Â |
|  | Yes | 1.47(0.69–3.10) | 0.319 | NA | NA |
Alcohol history | No | 1 | Â | Â | Â |
|  | Yes | 1.21 (0.51–2.90) | 0.668 | NA | NA |
Number of Lymph nodes |  | 0.99 (0.97–1.00) | 0.305 | NA | NA |
Number of positive LNs |  | 1.00 (0.94–1.05) | 0.878 | NA | NA |
Lymph node ratio |  | 2.02 (0.37–10.95) | 0.417 | NA | NA |
Margin status | Negative | 1 | Â | 1 | Â |
|  | Positive | 6.24(2.53–16.28) | 0.000* | 3.45(1.05–11.35) | 0.042* |
Lymphovascular | No | 1 | Â | Â | Â |
invasion | Yes | 2.00(0.71–5.66) | 0.192 | NA | NA |
Tumor grade | G1–G2 | 1 |  |  |  |
|  | G3–G4 | 0.97(0.43–2.20) | 0.942 | NA | NA |
Clinical T | T1–T2 | 1 |  |  |  |
|  | T3–T4 | 0.96(0.29–3.23) | 0.949 | NA | NA |
Clinical N | N0 | 1 | Â | Â | Â |
|  | N1–N3 | 1.86(0.84–4.12) | 0.123 | NA | NA |
Clinical stage | I–II | 1 |  |  |  |
|  | III–IV | 0.53(0.007–4.02) | 0.540 | NA | NA |
Mutation count |  | 0.99(0.98–1.01) | 0.185 | NA | NA |
Fraction Genome altered |  | 0.73(0.07–7.43) | 0.788 | NA | NA |
MDGPS |  | 1.43(1.23–1.67) | 0.000* | 1.29 (1.06–1.60) | 0.010* |