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Table 2 Univariable and multivariable Cox regression analysis for prediction of RFS in GSE27020 dataset

From: Identification and validation of methylation-driven genes prognostic signature for recurrence of laryngeal squamous cell carcinoma by integrated bioinformatics analysis

Factors

Subgroup

Univariable analysis

Multivariable analysis

HR (95% CI)

P

HR (95% CI)

P

Age

 

1.02(0.99–1.06)

0.193

NA

NA

Sex

Female

1

   
 

Male

21.94(0.34–32.16)

0.377

NA

NA

Smoking history

No

1

   
 

Yes

20.53(0.06–28.44)

0.679

NA

NA

Alcohol history

No

1

   
 

Yes

1.17 (0.58–2.33)

0.664

NA

NA

Tumor grade

G1–G2

1

   
 

G3–G4

0.90(0.64–1.26)

0.998

NA

NA

Clinical stage

I–II

1

   
 

III-IV

1.00(0.61–1.65)

0.525

NA

NA

Radiation therapy

Yes

  

NA

NA

 

No

2.22(0.98–4.99)

0.055

NA

NA

MDGPS

 

1.15(1.09–1.22)

0.000*

1.17(1.09–1.24)

0.000*

  1. HR hazard ratio, CI confidence intervals, RFS recurrence-free survival, NA not available
  2. These variables were eliminated in the multivariate cox regression model, so the HR and P values were not available.*P < 0.05