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Table 4 The top 10 KEGG, WikiPathway, and Reactome terms enriched by the node genes

From: Evaluation of the potential role of long non-coding RNA LINC00961 in luminal breast cancer: a case–control and systems biology study

Pathway p-value Node genes
KEGG
 Chemokine signaling pathway 2.67E−03 CCL14;GNG8;CCL19;RASGRP2;GNG11
 Viral myocarditis 3.22E−03 CAV1;FYN;SGCG
 Focal adhesion 3.25E−03 CAV2;CAV1;COL9A1;COL9A3;FYN
 Proteoglycans in cancer 3.39E−03 WNT10A;MRAS;CAV2;CAV1;HSPB2
 Cytokine–cytokine receptor interaction 3.60E−03 EDAR;ACVRL1;CCL14;IL3RA;CCL19;GDF5
 Apelin signaling pathway 4.97E−03 MRAS;GNG8;PPARGC1A;GNG11
 Ras signaling pathway 6.21E−03 MRAS;GNG8;RASGRP2;GNG11;FGF21
 PI3K–Akt signaling pathway 8.73E−03 IL3RA;COL9A1;GNG8;COL9A3;GNG11;FGF21
 Protein digestion and absorption 1.04E−02 COL11A2;COL9A1;COL9A3
 Morphine addiction 1.02E−02 PDE2A;GNG8;GNG11
WikiPathway
 Preimplantation Embryo 2.03E−04 DNMT3L;SIX3;ZFP42;SOX8
 Gastric Cancer Network 2 4.92E−04 PLAC8;COL9A1;COL9A3
 Adipogenesis 4.13E−03 NCOR2;KLF5;EBF1;PPARGC1A
 Focal Adhesion-PI3K–Akt–mTOR-signaling pathway 4.17E−03 IL3RA;COL11A2;GNG8;PPARGC1A;GNG11;FGF21
 Mesodermal Commitment Pathway 6.37E−03 FOXC1;KLF5;SOX17;LEFTY2
 Differentiation of white and brown adipocyte 6.89E−02 PLAC8;PPARGC1A
 PI3K–Akt Signaling Pathway 7.23E−03 IL3RA;COL9A1;GNG8;COL9A3;GNG11;FGF21
 Viral Acute Myocarditis 8.62E−0.3 CAV1;FYN;SGCG
 Statin Pathway 9.20E−03 CETP;PDIA2
 Chemokine signaling pathway 9.29E−03 GNG8;CCL19;RASGRP2;GNG11
Reactome
 GPCR ligand binding Homo sapiens 1.46E−05 WNT10A;NMB;S1PR1;GNG8;GPBAR1;AVPR1A;
CCL19;RGR;INSL3;GNG11;SSTR3
 Class A/1 (Rhodopsin-like receptors) Homo sapiens 2.18E−04 NMB;S1PR1;GPBAR1;AVPR1A;CCL19;
RGR;INSL3;SSTR3
 Collagen biosynthesis and modifying enzymes Homo sapiens 2.79E−04 PCOLCE2;COL11A2;COL9A1;COL9A3
 Signal Transduction Homo sapiens 3.73E−04 NCF4;RASGRP2;RLBP1;CDH5;SOX17;S1PR1;GNG8;POLR2F;FYN;CCL19;INSL3;WNT10A;NMB;CAV1;PDE2A;GPBAR1;AVPR1A;S100B;GNG11;SSTR3;NCOR2;IL3RA;COL9A1;COL9A3;RGR
 Extracellular matrix organization Homo sapiens 5.50E−04 ACAN;PCOLCE2;COL11A2;COL9A1;ICAM2;COL9A3;GDF5
 Transcriptional regulation of white adipocyte differentiation Homo sapiens 6.63E−04 NCOR2;KLF5;EBF1;PPARGC1A
 G alpha (s) signaling events Homo sapiens 7.37E−04 PDE2A;GNG8;GPBAR1;INSL3;GNG11
 Collagen formation Homo sapiens 8.74E−04 PCOLCE2;COL11A2;COL9A1;COL9A3
 GPCR downstream signaling Homo sapiens 1.21E−03 NMB;PDE2A;GPBAR1;AVPR1A;RASGRP2;GNG11;SSTR3;IL3RA;S1PR1;GNG8;CCL19;RGR;INSL3
 G alpha (i) signaling events Homo sapiens 1.31E−03 S1PR1;GNG8;CCL19;RGR;GNG11;SSTR3