Advancement in research and therapy of NF1 mutant malignant tumors

Table 1 The mechanisms of therapeutic resistance induced by NF1 mutations

Alteration induced by NF1 mutations	Downstream factors	Related therapeutic resistance	References
Inhibition of cisplatin-induced apoptosis	MCL1↓	Cisplatin	[35]
Heat shock response	HSF1↑	Trastuzumab, lapatinib	[44,45,46,47,48]
EMT	Invasion and migration	Targeted therapy	[51,52,53,54]
mTOR-HIF-1α-VEGF pathway↑	VEGF↑	TKIs	[57,58,59,60]
Ras-dependent pathways	Ras↑	TKIs	[8, 41, 49]

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