From: Advancement in research and therapy of NF1 mutant malignant tumors
Alteration induced by NF1 mutations | Downstream factors | Related therapeutic resistance | References |
---|---|---|---|
Inhibition of cisplatin-induced apoptosis | MCL1↓ | Cisplatin | [35] |
Heat shock response | HSF1↑ | Trastuzumab, lapatinib | |
EMT | Invasion and migration | Targeted therapy | |
mTOR-HIF-1α-VEGF pathway↑ | VEGF↑ | TKIs | |
Ras-dependent pathways | Ras↑ | TKIs |