Fig. 4
Factors related to tumor microenvironment (TME) differed significantly between patients under and equal and greater than 40 years old. a Correlation curve revealed a positive correlation between age and the level of TMB. Spearman test was used as statistical method. r = 0.31, P < 0.001; b Violin plot showed significantly higher level of TMB in patients equal and greater than 40 years old than those in patients under 40 years old. Wilcxon rank sum test was used as statistical method. loge (Wilcxon) = 8.99, P < 0.001; c Violin plot showed the different level of immune score, stromal score and ESTIMATE score between groups of patients under and equal and greater than 40 years old by analyzing data from microarray data in TCGA (TCGA- microarray), microarray data in CGGA (CGGA- microarray), primary GBM RNAseq data in CGGA (CGGA-RNAseq-pGBM), recurrent GBM RNAseq data in CGGA (CGGA-RNAseq-rGBM). Wilcxon rank sum test was used as statistical method. loge (Wilcxon) and P were provided on the right corner of each images