Fig. 4
Snail1 expression mediated colorectal cancer cell migration and chemotherapy resistance and was regulated by miR-138-5p. a Relative Snail1 mRNA level negatively correlated with relative miR-138-5p level (r = − 0.438, p < 0.001). b Relative Snail1 protein level negatively correlated with relative miR-138-5p level (r = − 0.52, p < 0.001). c Snail1 protein expression in stable cell lines. d In HCT116 cell lines, LV-mimics group was lower in the expression of Snail1 mRNA than LV-mNC group (p < 0.001). In DLD1 cell lines, LV-inhibitors group was higher in the expression of Snail1 mRNA than LV-INC group (p < 0.001). e, f Snail1 siRNA sequences with the best interference effect was screened for subsequent experiments. g In Fluorouracial treated DLD1 cell lines, the difference of relative cell viability between LV-inhibitor + Snail1 siRNA group and LV-INC + Snail1 siRNA group showed no statistical significance (p > 0.05). h In Doxorubicin treated DLD1 cell lines, the difference of relative cell viability between LV-inhibitor + Snail1 siRNA group and LV-INC + Snail1 siRNA group was not statistically significant (p > 0.05). i In Cisplatin treated DLD1 cell lines, the difference of relative cell viability between LV-inhibitor + Snail1 siRNA group and LV-INC + Snail1 siRNA group was not statistically significant (p > 0.05)