Fig. 1

miR-365 is poorly expressed in gastric precancerous lesions. a The box diagram of miR-365 expression analyzed by the starBase database (https://starbase.sysu.edu.cn/). The red box on the left indicates miR-365 expression in GC samples, and the purple box on the right indicates miR-365 expression in normal samples. b Expression of miR-365 in GC and adjacent normal tissues of 68 GC patients and 45 atrophic gastritis patients detected by RT-qPCR; c Expression of miR-365 in RGM-1, GES-1, MGC-803, MKN-45, HGC-27 cell lines detected by RT-qPCR; d Representative images of HE staining of gastric tissue in modeled rats and control rats (magnification, ×200); e Expression of miR-365 in gastric tissues of normal and GC rats determined by RT-qPCR (N = 6). *, p < 0.05, vs. adjacent normal tissues or control rats; Measurement data (mean ± standard deviation) between two groups were compared by unpaired t test, and those among multiple groups were compared by one-way ANOVA. Cell experiments were repeated three times