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Fig. 7 | Cancer Cell International

Fig. 7

From: Long non-coding RNA MIR100HG promotes the migration, invasion and proliferation of triple-negative breast cancer cells by targeting the miR-5590-3p/OTX1 axis

Fig. 7

MIR100HG knockdown inhibits tumour growth by upregulating miR-5590-3p in a xenograft mouse model MDA-MB-231 cell xenograft tumours stably transfected with MIR100HG shRNA or shRNA Ctrl vectors were obtained. The sizes of the tumours was then recorded. a, b Periodic monitoring of tumour dimensions after MIR100HG knockdown. c Tumour weights on day 28. d The expression levels of MIR100HG, miR-5590-3p and OTX1 in tumour tissues on day 28. e The protein levels of OTX1 in tumour tissues, as assessed by IHC assays. Scale bar: 50 µm. f, g The protein levels in the ERK/MAPK signalling pathway and the OTX1 protein in tumour tissues, as assessed by western blot analysis. *P < 0.05, **P < 0.01, ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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