The emerging roles of non-coding competing endogenous RNA in hepatocellular carcinoma

Xu, Gang; Xu, Wei-Yu; Xiao, Yao; Jin, Bao; Du, Shun-Da; Mao, Yi-lei; Zhang, Zhong-Tao

doi:10.1186/s12935-020-01581-5

Cancer Cell International

Table 3 Validated ceRNA networks shaped by the ceRNA function of circRNAs in HCC

From: The emerging roles of non-coding competing endogenous RNA in hepatocellular carcinoma

ceRNA network type	ceRNA member	Shared miRNA(s)	Competing target (mRNA)	ceRNA role	Experiments related to mechanism	Related HCC function mechanisms	Ref
CircRNA–miRNA–mRNA	circASAP1	miR-326, miR-532-5p	MAPK1, CSF-1	Oncogenic	Overexpression, shRNA knockdown in mouse xenografts	Proliferation and invasion	[103]
	circCdr1as	miR-1270	AFP	Oncogenic	Cellular	Proliferation and migration	[104]
	circCdr1as	miR-7	CCNE1, PIK3CD	Oncogenic	Cellular	Proliferation and invasion	[105]
	circABCC2	miR-665	ABCC2	Oncogenic	siRNA knockdown in mouse xenografts	Proliferation and invasion	[106]
	circ_104718	miR-218-5p	TXNDC5	Oncogenic	overexpression, siRNA knockdown in mouse xenografts, miR mimics, miR inhibitors	Proliferation, migration and invasion	[107]
	circ_104075	miR-582-3p	YAP	Oncogenic	CRISPR/Cas9 knockout of upstream positive regulator in mouse models	Proliferation	[108]
	circFBLIM1	miR-346	FBLIM1	Oncogenic	siRNA knockdown in mouse xenografts	Proliferation and invasion	[109]
	circ_100338	miR-141-3p	RHEB	Oncogenic	Cellular	Migration and invasion	[110]
	circ_0067934	miR-1324	FZD5	Oncogenic	siRNA knockdown in mouse xenografts	Proliferation, migration and invasion	[111]
	circ_0078710	miR-31	HDAC, CDK2	Oncogenic	Overexpression in mouse xenografts	Proliferation, migration and invasion	[112]
	circ_ CDYL	miR-892a, miR-328-3p	HDGF, HIF1AN	Oncogenic	shRNA knockdown in mouse xenografts	Proliferation and chemoresistance	[113]
	circ_ DB	miR-34a	USP7	Oncogenic	Overexpression, shRNA knockdown in mouse xenografts	Proliferation	[114]
	circ_101368	miR-200a	HMGB1, RAGE	Oncogenic	Cellular	Migration and invasion	[115]
	circ_001569	miR-411-5p, miR-432-5p	–	Oncogenic	shRNA knockdown in mouse xenografts	Migration and invasion	[116]
	circ_0015756	miR-7	FAK	Oncogenic	shRNA knockdown in mouse xenografts	Proliferation, migration and invasion	[117]
	circRBM23	miR-138	CCND3	Oncogenic	Overexpression, siRNA knockdown in mouse xenografts	Proliferation and migration	[118]
	circ_0016788	miR-486	CDK4	Oncogenic	shRNA knockdown in mouse xenografts	Proliferation and invasion	[119]
	circ_0000673	miR-767-3p	SET	Oncogenic	siRNA knockdown in mouse xenografts	Proliferation and invasion	[120]
	circ_0005075	miR-431	-------	Oncogenic	Cellular	Proliferation, migration and invasion	[121]
		miR-335	MAPK1	Oncogenic	siRNA knockdown in mouse xenografts	Proliferation, migration and invasion	[122]
	circ_BIRC6	miR-3918	Bcl2	Oncogenic	Overexpression, shRNA knockdown in mouse xenografts	Proliferation, migration and invasion	[123]
	circ_ZNF652	miR-203, miR-502-5p	Snail	Oncogenic	Knockdown in mouse xenografts	EMT	[124]
	circ ZFR	miR-3619-5p	CTNNB1	Oncogenic	Cellular	Proliferation and EMT	[125]
	circ_0008450	miR-214-3p	EZH2	Oncogenic	siRNA knockdown in mouse xenografts	Proliferation, migration and invasion	[126]
	circ_0000517	miR‑326	SMAD6	Oncogenic	shRNA knockdown in mouse xenografts	Proliferation, colony formation, migration, and invasion	[127]
	circNFATC3	miR-548I	NFATC3	Tumor suppressive	shRNA knockdown in mouse xenografts	Proliferation, migration and invasion	[128]
	circ_103809	miR-620	-------	Tumor suppressive	Cellular	Proliferation, migration and invasion	[129]
	circC3P1	miR-4641	PCK1	Tumor suppressive	Overexpression in mouse xenografts, miR mimics	Proliferation, migration and invasion	[130]
	circ_0091570	miR-1307	ISM1	Tumor suppressive	Overexpression, siRNA knockdown in mouse xenografts	Proliferation and migration	[131]
	circ_0001649	miR-127-5p, miR-612, miR-4688	SHPRH	Tumor suppressive	shRNA knockdown in mouse xenografts	Proliferation and migration	[132]
	circMTO1	miR-9	p21	Tumor suppressive	siRNA knockdown in mouse xenografts	Proliferation and invasion	[133]
	cSMARCA5	miR-17-3p, miR-181b-5p	TIMP3	Tumor suppressive	Overexpression in mouse xenografts	Proliferation and migration	[134]
	circSETD3	miR-421	MAPK-14	Tumor suppressive	Overexpression in mouse xenografts	Proliferation	[135]
	circTRIM33-12	miR-191	TET1	Tumor suppressive	Overexpression, shRNA knockdown in mouse xenografts	Proliferation, migration, invasion and immune evasion	[136]
	circADAMTS13	miR-484	ADAMTS13	Tumor suppressive	Cellular	Proliferation	[137]
	circADAMTS14	miR-572	RCAN1	Tumor suppressive	Overexpression in mouse xenografts, miR mimics, miR inhibitors	Proliferation and invasion	[138]
	circSMAD2	miR-629	SMAD2	Tumor suppressive	Cellular	Migration, invasion and EMT	[139]
	circLARP4	miR-761	RUNX3	Tumor suppressive	shRNA knockdown in mouse xenografts	Proliferation	[140]
	circLARP4	miR-761	RUNX3	Tumor suppressive	shRNA knockdown in mouse xenografts	Proliferation	[140]
	circ_0005986	miR-129-5p	Notch1	Tumor suppressive	Cellular	Proliferation	[141]

ceRNA: competing endogenous RNA; circRNA: circularRNA; mRNAs: messenger RNAs; miRNA: microRNA; HCC: hepatocellular carcinoma; EMT: epithelial–mesenchymal transition; Ref: reference

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ISSN: 1475-2867

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