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Table 3 Validated ceRNA networks shaped by the ceRNA function of circRNAs in HCC

From: The emerging roles of non-coding competing endogenous RNA in hepatocellular carcinoma

ceRNA network type ceRNA member Shared miRNA(s) Competing target (mRNA) ceRNA role Experiments related to mechanism Related HCC function mechanisms Ref
CircRNA–miRNA–mRNA circASAP1 miR-326, miR-532-5p MAPK1, CSF-1 Oncogenic Overexpression, shRNA knockdown in mouse xenografts Proliferation and invasion [103]
  circCdr1as miR-1270 AFP Oncogenic Cellular Proliferation and migration [104]
  circCdr1as miR-7 CCNE1, PIK3CD Oncogenic Cellular Proliferation and invasion [105]
  circABCC2 miR-665 ABCC2 Oncogenic siRNA knockdown in mouse xenografts Proliferation and invasion [106]
  circ_104718 miR-218-5p TXNDC5 Oncogenic overexpression, siRNA knockdown in mouse xenografts, miR mimics, miR inhibitors Proliferation, migration and invasion [107]
  circ_104075 miR-582-3p YAP Oncogenic CRISPR/Cas9 knockout of upstream positive regulator in mouse models Proliferation [108]
  circFBLIM1 miR-346 FBLIM1 Oncogenic siRNA knockdown in mouse xenografts Proliferation and invasion [109]
  circ_100338 miR-141-3p RHEB Oncogenic Cellular Migration and invasion [110]
  circ_0067934 miR-1324 FZD5 Oncogenic siRNA knockdown in mouse xenografts Proliferation, migration and invasion [111]
  circ_0078710 miR-31 HDAC, CDK2 Oncogenic Overexpression in mouse xenografts Proliferation, migration and invasion [112]
  circ_ CDYL miR-892a, miR-328-3p HDGF, HIF1AN Oncogenic shRNA knockdown in mouse xenografts Proliferation and chemoresistance [113]
  circ_ DB miR-34a USP7 Oncogenic Overexpression, shRNA knockdown in mouse xenografts Proliferation [114]
  circ_101368 miR-200a HMGB1, RAGE Oncogenic Cellular Migration and invasion [115]
  circ_001569 miR-411-5p, miR-432-5p Oncogenic shRNA knockdown in mouse xenografts Migration and invasion [116]
  circ_0015756 miR-7 FAK Oncogenic shRNA knockdown in mouse xenografts Proliferation, migration and invasion [117]
  circRBM23 miR-138 CCND3 Oncogenic Overexpression, siRNA knockdown in mouse xenografts Proliferation and migration [118]
  circ_0016788 miR-486 CDK4 Oncogenic shRNA knockdown in mouse xenografts Proliferation and invasion [119]
  circ_0000673 miR-767-3p SET Oncogenic siRNA knockdown in mouse xenografts Proliferation and invasion [120]
  circ_0005075 miR-431 ------- Oncogenic Cellular Proliferation, migration and invasion [121]
   miR-335 MAPK1 Oncogenic siRNA knockdown in mouse xenografts Proliferation, migration and invasion [122]
  circ_BIRC6 miR-3918 Bcl2 Oncogenic Overexpression, shRNA knockdown in mouse xenografts Proliferation, migration and invasion [123]
  circ_ZNF652 miR-203, miR-502-5p Snail Oncogenic Knockdown in mouse xenografts EMT [124]
  circ ZFR miR-3619-5p CTNNB1 Oncogenic Cellular Proliferation and EMT [125]
  circ_0008450 miR-214-3p EZH2 Oncogenic siRNA knockdown in mouse xenografts Proliferation, migration and invasion [126]
  circ_0000517 miR‑326 SMAD6 Oncogenic shRNA knockdown in mouse xenografts Proliferation, colony formation, migration, and invasion [127]
  circNFATC3 miR-548I NFATC3 Tumor suppressive shRNA knockdown in mouse xenografts Proliferation, migration and invasion [128]
  circ_103809 miR-620 ------- Tumor suppressive Cellular Proliferation, migration and invasion [129]
  circC3P1 miR-4641 PCK1 Tumor suppressive Overexpression in mouse xenografts, miR mimics Proliferation, migration and invasion [130]
  circ_0091570 miR-1307 ISM1 Tumor suppressive Overexpression, siRNA knockdown in mouse xenografts Proliferation and migration [131]
  circ_0001649 miR-127-5p, miR-612, miR-4688 SHPRH Tumor suppressive shRNA knockdown in mouse xenografts Proliferation and migration [132]
  circMTO1 miR-9 p21 Tumor suppressive siRNA knockdown in mouse xenografts Proliferation and invasion [133]
  cSMARCA5 miR-17-3p, miR-181b-5p TIMP3 Tumor suppressive Overexpression in mouse xenografts Proliferation and migration [134]
  circSETD3 miR-421 MAPK-14 Tumor suppressive Overexpression in mouse xenografts Proliferation [135]
  circTRIM33-12 miR-191 TET1 Tumor suppressive Overexpression, shRNA knockdown in mouse xenografts Proliferation, migration, invasion and immune evasion [136]
  circADAMTS13 miR-484 ADAMTS13 Tumor suppressive Cellular Proliferation [137]
  circADAMTS14 miR-572 RCAN1 Tumor suppressive Overexpression in mouse xenografts, miR mimics, miR inhibitors Proliferation and invasion [138]
  circSMAD2 miR-629 SMAD2 Tumor suppressive Cellular Migration, invasion and EMT [139]
  circLARP4 miR-761 RUNX3 Tumor suppressive shRNA knockdown in mouse xenografts Proliferation [140]
  circLARP4 miR-761 RUNX3 Tumor suppressive shRNA knockdown in mouse xenografts Proliferation [140]
  circ_0005986 miR-129-5p Notch1 Tumor suppressive Cellular Proliferation [141]
  1. ceRNA: competing endogenous RNA; circRNA: circularRNA; mRNAs: messenger RNAs; miRNA: microRNA; HCC: hepatocellular carcinoma; EMT: epithelial–mesenchymal transition; Ref: reference