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Table 4 Validated ceRNA networks shaped by the ceRNA function of pseudogene in HCC

From: The emerging roles of non-coding competing endogenous RNA in hepatocellular carcinoma

ceRNA network type

ceRNA member

Shared miRNA(s)

Competing target (mRNA)

ceRNA role

Experiments related to mechanism

Related HCC function mechanisms

Ref

Pseudogene–miRNA–mRNA

OCT4-pg4

miR-145

OCT4

Oncogenic

siRNA knockdown in mouse xenografts

Proliferation and colony formation

[10]

 

RACGAP1P

miR-15-5p

RACGAP1

Oncogenic

Overexpression in mouse xenografts

Proliferation and migration

[147]

 

INTS6P1

miR-17-5p

INTS6

Tumor suppressive

Overexpression in mouse xenografts

Apoptosis and cell growth

[148]

  1. ceRNA: competing endogenous RNA; mRNAs: messenger RNAs; miRNA: microRNA; HCC: hepatocellular carcinoma; Ref: reference